Line-of-sight
Line-of-sight refers to an unobstructed, straight path between an observer's eyes and a point in the environment. In other words, it's the clear and direct visual connection between the observer and the target.
Contents
When firing a missile weapon, combatants must be able to trace a direct line of sight between themselves and the target hex. Common obstructions to line of sight include buildings and structures, terrain features, vegetation, atmospheric conditions, curvature of the earth and differences in elevation.
Targeting in Combat
When firing missiles into an ongoing melee, hurled and fired weapons can be employed by drawing a straight line between the observer and target from one combat hex to another. Where the shot is obstructed by a friendly combatant, the shot cannot be taken. Otherwise, it's always assumed that the hit or missed shot will either cause damage to the target or fly past harmlessly ... unless a natural '2' is rolled, in which case the missile is considered friendly fire.
Cover
Objects that are partly but not wholly obscured by obstacles can be targeted. However, it must be determined what percentage of the whole target is visible; this is usually rated in 10% increments, simplifying the roll that must be made if a "hit" is achieved. For example, an archer fires at a target, of which 40% can be seen. If the archer hits, a second roll is made on a d10. If the d10 result is 4 or less, the hit counts; if not, then the missile has struck the obstacle and either stuck or bounded away harmlessly.
In extreme situations, players may wish to fire at targets that have as little as 3% or less that's visible. This is actionable, but keep in mind that most of the time, a hidden combatant won't show any visibility when hiding.